Diabetes
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Generic
Glucotrol (Glipizide) 10 mg
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| $39.42($0.65 per pill) | 60 pills |
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Product Description
Glucotrol (Glipizide)
DRUG CLASS AND MECHANISM : Glipizide is a drug that should be accepted orally. It is applied for the treatment of type 2 diabetes. It belongs to a class of drugs called sulfonylurea. This group also includes glimepiride (Amaryl), glyburide (Micronase, Diabeta), tolbutamide (Orinase) and tolazamide (Tolinase). Insulin is a hormone produced by the pancreas. It causes a decline of glucose blood's levels by decreasing the quantity of glucose produced by the liver. It is also extends the removal of glucose from the blood. Patients with type 2 diabetes have high glucose (sugar) levels in their blood because of the resistance of cells in their bodies to the effect of the insulin. Besides this the liver produces too much glucose. In addition, in type 2 diabetes the pancreas is unable to produce the extended quantity of insulin that are needed to overcome the resistance of the cells. Glipizide stimulates the pancreas to produce more insulin to decreace blood glucose. Glipizide is not a cure for diabetes.
GENERIC AVAILABLE : YES.
PRESCRIPTION : YES.
PREPARATIONS : Immediate-release tablets; 5mg, 10mg. Extended-release tablets; 2.5, 5, and 10 mg.
STORAGE : Keep below 86°F (30°;C).
PRESCRIBED FOR : Glipizide is appointed together with diet and exercise to lower blood glucose in patients with type 2 diabetes.
DOSING : At the begining the advised dose for immediate release tablets is 5 mg accepted 30 minutes before a meal. The maximum dose is 40 mg a day. Doses higher than 15 mg per day should be divided. The starting dose of extended-release tablets is 5 mg daily up to a maximum dose of 20 mg a day. Patients using immediate release tablets may be converted to the nearest equivalent extended-release dose.
DRUG INTERACTIONS : The action of glipizide may be prolonged by alcohol. It delays the absorption and elimination of glipizide. Patients applying glipizide shouldn't consume alcohol. Cholestyramine may decrease the effect of glipizide by lowering the absorption, that's why glipizide should be accepted 1-2 hours before cholestyramine. Fluconazole (Diflucan) may extend the effect of glipizide by increasing the absorption. There are many drugs that can potentially increase or decrease the effect of glipizide by increasing or decreasing glucose levels. Such medicines as nonsteroidal anti-inflammatory drugs (e.g., ibuprofen), sulfa drugs, warfarin, miconazole, and beta-blockers (e.g., propranolol) can cause low blood glucose (hypoglycemia). On the other hand combination with thiazide diuretics, corticosteroids, thyroid medicines, estrogens, niacin, phenytoin, and calcium channel blocking drugs (e.g., diltiazem) can lead to high blood glucose (hyperglycemia). That's why patients accepted such drugs should be monitored closely for loss of glucose control.
PREGNANCY : There have been no researches in pregnant women.
NURSING MOTHERS : It is unknown about glipizide excretion in breast milk.
SIDE EFFECTS AND PRECAUTIONS : The most common side effects are headache, dizziness, diarrhea, and gas. Sometimes skin rashes can appear and cause itching, hives, or a diffuse measles-like rash. Glipizide can also cause such serious but rare side effects as hepatitis, jaundice, low sodium concentration and hypoglycemia. The risk of hypoglycemia extends in case of using glipizide is combination with other glucose reducing agents.
