Diabetes
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Actos (Pioglitazone) 15 mg
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| $59.04($1.97 per pill) | 30 pills |
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| $104.84($1.75 per pill) | 60 pills |
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| $138.37($1.54 per pill) | 90 pills |
$39.00 | ||||
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Actos (Pioglitazone) 30 mg
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| $101.87($3.39 per pill) | 30 pills |
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| $180.93($3.01 per pill) | 60 pills |
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| $238.60($2.65 per pill) | 90 pills |
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Generic Actos (Pioglitazone) 45 mg
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| $122.20($4.08 per pill) | 30 pills |
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| $217.07($3.62 per pill) | 60 pills |
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| $286.57($3.18 per pill) | 90 pills |
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Product Description
Actos (Pioglitazone)
DRUG CLASS AND MECHANISM : Pioglitazone is a medicine that reduces the quantity of glucose (sugar) in the blood. It belongs to a class of anti-diabetic drugs named "thiazolidinediones" which are used when treating type II diabetes. The other member in this class is rosiglitazone (Avandia). (Another member of this class, troglitazone or Rezulin, was excluded from the market because of liver toxicity.) Patients which are ill with type II diabetes cannot make enough insulin, and the cells of their body do not respond normally to the lowered amounts of insulin presented in organism. (Insulin is the hormone made by the pancreas that stimulates cells to transfer glucose from the blood.) Pioglitazone often is called "insulin sensitizer" because it adds to the insulin receptors on cells throughout the body and makes the cells work more sensitive (more responsive) to insulin. The resuld of it is the process of glucose removing from the blood. In order for pioglitazone work, some insulin must be produced by the pancreas Pioglitazone also reduces the level of glucose in the blood by reducing the production and secretion of glucose into the blood by the patient. More over, pioglitazone may correct the amount of lipids (fats) in the blood. Specifically, it promotes decreasing of triglycerides and increasing of the "good" (HDL) cholesterol. FDA gave its approval for pioglitazone on July 16, 1999.
GENERIC AVAILABLE : No.
PRESCRIPTION : YES.
PREPARATIONS : Tablets: 15, 30 and 45 mg.
STORAGE : Tablets should be stored at room temperature, 15-30°C (59-86°F).
PRESCRIBED FOR : Pioglitazone is applied for the treatment of type II diabetes on a level with a healthy diabetic diet, regular exercise, weight control, smoking reduction, and careful observation of the level of blood glucose. Useing of pioglitazone is allowed both alone or in combination with metformin, a medicine of a different class of anti-diabetic drugs, that also promotes the reduction of the level of blood glucose. Pioglitazone is not recommended in treating type I diabetes (where there are a lack of insulin or even apsence) from the moment naturally-secreted insulin was required to be effective. But pioglitazone is accepted for treating type II diabetes in mixture with insulin the same way as ohter class of anti-diabetic drugs, the sulfonylureas.
DOSING : The right dose of pioglitazone is from 15 to 45 mg taken one time daily. Pioglitazone may be taken any time of the day, with or without meals. Missing one day dose should not be taken the next day.
DRUG INTERACTIONS : There are no any investigation about the drug interactions of pioglitazone with other medicines. Nevertheless, taking the similar to pioglitazone medecine called thiazolidinedione may lower the effectiveness of oral contraceptives (potentially leading to pregnancy), so it needs caution when using pioglitazone with an oral contraceptive. Clinical research of treating by pioglitazone 15-45mg did not show the full list of changes in blood levels for such drugs as: glipizide, digoxin, warfarin or metformin. What is more, pioglitazone didn't change the clotting of blood to the condition when it was necessary to enter the doses of warfarin to make the blood thin.
PREGNANCY : Studies of pioglitazone in pregnant women was not done. So during the pregnancy it is posible to use pioglitazone only if the doctor considers the potential risks are proved.
NURSING MOTHERS : There are no information if pioglitazone is secreted in breast milk. Therefore, there is no assurance that taking pioglitazone by the mother is safe to a nursing.
SIDE EFFECTS AND PRECAUTIONS : When observing in clinical trials with pioglitazone alone or in tandem with sulfonylureas, metformin, or insulin the most common side effects were picked up. Such consequences as upper respiratory tract infection, headache, sinusitis, muscle aches, tooth disorders, hypoglycemia, and sore throat have a place. Moreover, fluid accumulation (edema) happened in less than 5% of patients treating by pioglitazone alone in contrast to 15% of patients taking pioglitazone and insulin (as in comparison with 2% and 7% of patients receiving placebo, accordingly). Heart failure can be the after-effect of fluid accumulation.
