Anti Depressants
Paxil, Paxil CR (Paroxetine), BestDrugsNow.com - online pharmacy.
Generic Paxil, Paxil CR (Paroxetine) 10 mg
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| $78.84($1.31 per pill) | 60 pills |
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| $98.54($1.09 per pill) | 90 pills |
$16.00 | ||||
Generic Paxil, Paxil CR (Paroxetine) 20 mg
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| $71.19($2.37 per pill) | 30 pills |
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| $126.47($2.11 per pill) | 60 pills |
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| $166.95($1.85 per pill) | 90 pills |
$47.00 | ||||
Generic Paxil, Paxil CR (Paroxetine) 30 mg
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| $101.70($3.39 per pill) | 30 pills |
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| $180.68($3.01 per pill) | 60 pills |
$23.00 | ||||
| $238.50($2.56 per pill) | 90 pills |
$67.00 | ||||
Generic Paxil, Paxil CR (Paroxetine) 40 mg
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| $132.21($4.41 per pill) | 30 pills |
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| $234.88($3.92 per pill) | 60 pills |
$29.00 | ||||
| $310.05($3.44 per pill) | 90 pills |
$87.00 | ||||
Product Description
Paxil, Paxil CR (Paroxetine)
DRUG CLASS AND MECHANISM : Paroxetine is an anti-depressant drug that influence on the chemicals that nerves in the brain use to be in contact with one another. Neurotransmitters are the chemical messengers that are released by one nerve and taken up by other one. If some neurotransmitters that have been released are not taken up by other nerves then they are taken up by the nerves that release them ("reuptake"). Many experts consider it to be an disproportion among the amounts of the different neurotransmitters that are released and these process becames the reason of depression. Paroxetine functions by preventing the reuptake of serotonin by the nerves that release it. This action allows more serotonin to be available to be captured up by other nerves. Paroxetine belongs to the class of drugs called selective serotonin reuptake inhibitors (SSRIs). Fluoxetine (Prozac) and sertraline (Zoloft) are also included in the class.
GENERIC AVAILABLE : YES.
PRESCRIPTION : YES.
PREPARATIONS : The drug is provided in tablets (oval): 10 mg (yellow), 20 mg (pink), 30 mg (blue), and 40 mg (green).
Paxil CR, a controlled release form of paroxetine, is also made in tablets of 12.5, 25, and 37.5 mg.
STORAGE : Tablets should be stored at room temperature, 15- 30°C (59-86°F).
PRESCRIBED FOR : Paroxetine is indicated for use of depression, obsessive-compulsive disorders,
panic disorders, and premenstrual dysphoric disorder.
DOSING : Usually the drug is given as a single daily dose, mainly in the morning. The full effect can be observed after a few weeks of therapy. For obsessive- compulsive disorders and panic disorders it should be prescribed higher dose than for depression. Some changes of doses are possible. It is usually done to find the optimal dose. It is recommended to make the dose lower for elderly patients, debilitated persons, and patients with certain kidney or liver diseases because they metabolize and eliminate paroxetine more slowly and, therefore, it may be a reason for high blood levels.
DRUG INTERACTIONS : All SSRIs, to which paroxetine belongs, should not be taken together with any of the MAO (mono-amine oxidase) inhibitor-class of anti-depressants (such as isocarboxazid (Marplan), phenelzine (Nardil), tranylcypromine (Parnate), and procarbazine (Matulane). Confusion, high blood pressure, tremor, and increased activity can be a result of the treatment by the drug. The same type of co-operaction may also take place when combining with selegiline (Eldepryl), fenfluramine (Pondimin), and dexfenfluramine (Redux). The anti-ulcer medication, cimetidine (Tagamet) can increase the amount of paroxetine in the blood, possibly leading to side effects. It has not been reported if paroxetine is well combined in patients taking warfarin (Coumadin). And in order to avoid bleeding it is better not to take risks . Tryptophan can be a reason for headaches, nausea, sweating, and dizziness when taken with any SSRI. The effectivness may reduces if phenytoin (Dilantin) and phenobarbital decrease the amount of paroxetine in the body. For premenstrual dysphoric disorder Paxil CR is accepted for continuous or intermittent therapy . For intermittent therapy, women take Pacil CR once a day during the two-week period that is the prior to the onset of their menstrual cycle rather than during all month.
PREGNANCY : There are no information if paroxetine is dangerous for pregnant women.
NURSING MOTHERS : There were no research if paroxetine is secreted in breast milk.
SIDE EFFECTS : The most common side effects when treating with paroxetine are anxiety, sweating, nausea, decreased appetite, somnolence (sleepiness), dizziness, insomnia, and male sexual disturbances. About 18% of patients taking paroxetine can feel dry mouth. The withdrawal of treatment with many anti-depressants may cause troublesome symptoms. When taking anti-depressants, like paroxetine, classified as SSRI's symptoms can be frequent. Between 17% to 30% with paroxetine and fluvoxamine (Luvox) but less than 5% with other SSRI's at least have the rate of symptoms upon withdrawal. Dizziness, tiredness, tingling of the extremities, nausea, vivid dreams, irritability, and poor mood are the most common symptoms of withdrawal. Other symptoms such as visual disturbances and headaches can also appear. Withdrawal reactions have been noticed upon withdrawing SSRI's after an average of 12 to 36 weeks of treatment, but after as few as 5 weeks. It is known if treatment is stopped even for a little period by gradually reducing the dose of the SSRI, symptoms have occurred despite tapering. They usually appear within a few days of discontinuing the drug and last for an average of 12 days (up to 21 days). To relieve them it is needed to restore the discontinued drug within 24 hours. Potentially there is a danger of development of depression to worsen and even to suicide but it can occur just to a small number of patients. It is too hard to determine in a depressed patients if this effects caused by treatment or not, and as for suicide is itself a consequence of depression. Moreover, the evidence supporting these potential side effects is so weak that it is still impossible to give an answer about the SSRIs influence on worsening depression and suicide. Until more investigations is done, patients receiving SSRIs should be observed more carefully for worsening depression and suicidal trends.
